Pub. Date : 1996 Oct
PMID : 8862135
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 2 | Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 3 | Furthermore, constitutive TNF alpha, demonstrated to be present in several brain areas, was significantly decreased following administration of the alpha 2-adrenergic agonist clonidine (0.6 mg/kg, i.p., twice daily) to rats for either 1 or 14 days, without a change in TNF alpha mRNA accumulation. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 4 | We next investigated whether the presynaptic sensitivity to TNF alpha was changed after clonidine administration to rats. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 5 | TNF alpha enhanced, rather than inhibited, [3H]-NE release after 1 day of clonidine administration, while a suppressed sensitivity to TNF alpha was observed in the hippocampus after 14 days of clonidine administration. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 6 | TNF alpha enhanced, rather than inhibited, [3H]-NE release after 1 day of clonidine administration, while a suppressed sensitivity to TNF alpha was observed in the hippocampus after 14 days of clonidine administration. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 7 | In addition, in the presence of idazoxan, TNF alpha potentiation of [3H]-NE release after 1 day clonidine administration was reversed to a decreased inhibition as compared to control slices exposed to idazoxan. | Clonidine | tumor necrosis factor | Rattus norvegicus |
| 8 | Therefore, the temporary reversal in the presynaptic TNF alpha response after 1 day of clonidine administration illustrates a mechanism of action for its persistent antihypertensive effect, its transient sedative and antihyperpathic effects, and its acute ability to promote antidepressants. | Clonidine | tumor necrosis factor | Rattus norvegicus |