Title : Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

Pub. Date : 1996 Jun

PMID : 8858389






2 Functional Relationships(s)
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1 Sildenafil is a selective inhibitor of PDE5 with a mean IC50 of 0.0039 microM. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
2 Moreover, in a clinical study of 12 patients with erectile dysfunction without an established organic cause, we have shown sildenafil to enhance the erectile response (duration and rigidity of erection) to visual sexual stimulation, thus highlighting the important role of PDE5 in human penile erection. Sildenafil Citrate phosphodiesterase 5A Homo sapiens