Title : Insulin-induced in situ phosphorylation of the insulin receptor located in the plasma membrane versus endosomes.

Pub. Date : 1996 Oct 3

PMID : 8858098






1 Functional Relationships(s)
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1 We find that following insulin stimulation (i) 90% of the receptor-associated phosphate is located in the endosomal compartment, (ii) the endosomal receptor is most highly phosphorylated in the tyrosine kinase domain, and (iii) significant levels of juxtamembrane domain phosphorylation are detected in the endosomal receptor. Phosphates insulin Homo sapiens