Title : Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Pub. Date : 1996 Oct 1

PMID : 8855335






2 Functional Relationships(s)
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1 We have identified a nonneuroleptic phenothiazine previously used in man (methylene blue, MB), which reverses the proteolytic stability of protease-resistant PHFs by blocking the tau-tau binding interaction through the repeat domain. Methylene Blue microtubule associated protein tau Homo sapiens
2 We have identified a nonneuroleptic phenothiazine previously used in man (methylene blue, MB), which reverses the proteolytic stability of protease-resistant PHFs by blocking the tau-tau binding interaction through the repeat domain. Methylene Blue microtubule associated protein tau Homo sapiens