Title : Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

Pub. Date : 1996 Oct 10

PMID : 8849730






1 Functional Relationships(s)
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1 Here we show that non-phosphorylated recombinant tau isoforms with three microtubule-binding repeats form paired helical-like filaments under physiological conditions in vitro, when incubated with sulphated glycosaminoglycans such as heparin or heparan sulphate. Heparitin Sulfate microtubule associated protein tau Homo sapiens