Title : Interleukin 1 beta, but not tumor necrosis factor, enhances neurogenic vasodilatation in the rat skin: involvement of nitric oxide.

Pub. Date : 1995 Jul

PMID : 8846404






6 Functional Relationships(s)
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1 In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. Capsaicin interleukin 1 beta Rattus norvegicus
2 In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. Capsaicin interleukin 1 beta Rattus norvegicus
3 IL-1 beta was without effect on blood flow by its own but dose dependently enhanced the hyperemia due to capsaicin (0.3 microgram). Capsaicin interleukin 1 beta Rattus norvegicus
4 did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperemic response to capsaicin. Capsaicin interleukin 1 beta Rattus norvegicus
5 Systemic pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-induced hyperemia and prevented the facilitatory effect of IL-1 beta. Capsaicin interleukin 1 beta Rattus norvegicus
6 These data indicate that IL-1 beta but not TNF enhances the cutaneous hyperemic response to capsaicin. Capsaicin interleukin 1 beta Rattus norvegicus