Title : Human monocyte response to cementum extracts from periodontally diseased teeth: effect of conditioning with tetracycline.

Pub. Date : 1996 Jul

PMID : 8832479






3 Functional Relationships(s)
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1 Pretreatment of diseased cementum with tetracycline (50 mg/ml) was found to block the secretion of TNF alpha from cementum-stimulated monocytes. Tetracycline tumor necrosis factor Homo sapiens
2 The direct addition of tetracycline to cementum-stimulated monocyte culture was found to block TNF alpha secretion in a dose dependent manner. Tetracycline tumor necrosis factor Homo sapiens
3 In addition, tetracycline was found to be a potent inhibitor of TNF alpha secretion by cementum-stimulated monocytes, suggesting a novel mechanism for this drug in periodontal therapy. Tetracycline tumor necrosis factor Homo sapiens