Title : Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides.

Pub. Date : 1995 Dec 1

PMID : 8830310






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide. nac acetylcholinesterase (Cartwright blood group) Homo sapiens
2 No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a "pathological chaperone" inducing a conformational transition from A beta nac into A beta ac in vitro. nac acetylcholinesterase (Cartwright blood group) Homo sapiens