Pub. Date : 1996
PMID : 8826527
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have found evidence that part of the survival-promoting activity of GM1 is dependent on the presence, dimerization, and activation of the Trk NGF receptor tyrosine kinase and that GM1 causes a detectable increase in Trk receptor autophosphorylation. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 2 | We have found evidence that part of the survival-promoting activity of GM1 is dependent on the presence, dimerization, and activation of the Trk NGF receptor tyrosine kinase and that GM1 causes a detectable increase in Trk receptor autophosphorylation. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 3 | We postulate that exogenously supplied GM1 causes increased ligand-independent dimerization of Trk molecules within membranes, thereby leading to its activation and promotion of survival. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |