Title : Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine.

Pub. Date : 1996 Jul

PMID : 8818577






1 Functional Relationships(s)
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1 Selective cytochrome P450 inhibitors for CYP1A1/2 (furafylline and 7,8-benzoflavone) and CYP3A4 (troleandomycin, gestodene, and ketoconazole) inhibited the formation of desmethylcyclobenzaprine, a major metabolite of cyclobenzaprine, in human liver microsomes. alpha-naphthoflavone cytochrome P450 family 1 subfamily A member 1 Homo sapiens