Title : Inhibition of rat liver microsomal NADPH cytochrome P450 reductase by glutathione and glutathione disulfide.

Pub. Date : 1996 Sep 13

PMID : 8806659






2 Functional Relationships(s)
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1 To delineate the mechanism of inhibition of microsomal lipid peroxidation by GSH + GSSG, we examined the effects of these compounds on cytochrome P-450 reductase (EC 1.6.2.4), an important component of the NADPH-dependent enzymatic lipid peroxidation system. NADP cytochrome p450 oxidoreductase Rattus norvegicus
2 We speculate that one possible mechanism for the inhibition of NADPH-dependent lipid peroxidation by GSH + GSSG is, in part, due to inhibition of NADPH cytochrome P-450 reductase, thus affecting the initiation phase of lipid peroxidation. NADP cytochrome p450 oxidoreductase Rattus norvegicus