Title : Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

Pub. Date : 1996 Sep 15

PMID : 8805618






1 Functional Relationships(s)
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1 Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism. Inositol inositol polyphosphate-5-phosphatase D Homo sapiens