Title : Okadaic acid potentiates 3-methylcholanthrene-induced CYP2A8 gene expression in primary cultures of Syrian hamster hepatocytes: possible involvement of activator protein-1.

Pub. Date : 1996 Sep

PMID : 8794894






3 Functional Relationships(s)
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1 The dose-dependent effect of OA on 3-MC-induced CYP2A8 expression corresponded to that of OA on c-fos and jun-D mRNA induction and on the activation of AP-1-dependent gene transcription. Methylcholanthrene proto-oncogene c-Fos Mesocricetus auratus
2 The expression of c-fos and jun-D mRNA induced by OA preceded the expression of CYP2A8 mRNA potentiated by co-treatment with 3-MC and OA. Methylcholanthrene proto-oncogene c-Fos Mesocricetus auratus
3 Treatment with anisomycin and cycloheximide also potentiated 0.1 microM 3-MC-induced coumarin 7-hydroxylase activity, induced c-fos and jun-D mRNA expression, and activated AP-1-dependent gene transcription in the hepatocytes. Methylcholanthrene proto-oncogene c-Fos Mesocricetus auratus