Title : Okadaic acid potentiates 3-methylcholanthrene-induced CYP2A8 gene expression in primary cultures of Syrian hamster hepatocytes: possible involvement of activator protein-1.

Pub. Date : 1996 Sep

PMID : 8794894






1 Functional Relationships(s)
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1 Treatment with anisomycin and cycloheximide also potentiated 0.1 microM 3-MC-induced coumarin 7-hydroxylase activity, induced c-fos and jun-D mRNA expression, and activated AP-1-dependent gene transcription in the hepatocytes. Anisomycin proto-oncogene c-Fos Mesocricetus auratus