Pub. Date : 1996 Oct
PMID : 8794306
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A proline-rich repeat sequence [(Pxx)4] in Nef occurring between amino acid residues 69 to 78 is highly conserved and bears strong resemblance to a defined consensus sequence identified as an SH3 binding domain present in several proteins which can interact with the SH3 domain of various signalling and cytoskeletal proteins. | Proline | S100 calcium binding protein B | Homo sapiens |
| 2 | Binding and coprecipitation assays with short synthetic peptides corresponding to the proline-rich repeat sequence [(Pxx)4] of Nef and the SH2, SH3, or SH2 and SH3 domains of Lck revealed that the interaction between these two proteins is at least in part mediated by the proline repeat sequence of Nef and the SH3 domain of Lck. | Proline | S100 calcium binding protein B | Homo sapiens |
| 3 | In addition to direct binding to full-length Nef, MAPK was also shown to bind the same proline repeat motif. | Proline | S100 calcium binding protein B | Homo sapiens |