Pub. Date : 1995 Dec
PMID : 8786635
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCl4-mediated malondialdehyde (MDA) formation was increased in rifampicin-treated liver microsomes, demonstrating that rifampicin was capable of increasing the NADPH-dependent metabolism of CCl4 catalyzed by P-450 2E1 to produce free radicals. | Free Radicals | chemokine (C-C motif) ligand 4 | Mus musculus |
| 2 | CCl4-mediated malondialdehyde (MDA) formation was increased in rifampicin-treated liver microsomes, demonstrating that rifampicin was capable of increasing the NADPH-dependent metabolism of CCl4 catalyzed by P-450 2E1 to produce free radicals. | Free Radicals | chemokine (C-C motif) ligand 4 | Mus musculus |
| 3 | Therefore, the protective effect of rifampicin against CCl4 hepatotoxicity appeared to result from the direct inhibition of lipid peroxidation generated by CCl4-derived free radicals. | Free Radicals | chemokine (C-C motif) ligand 4 | Mus musculus |