Title : Synergistic interactions between COMT-/MAO-inhibitors and L-Dopa in MPTP-treated mice.

Pub. Date : 1995

PMID : 8785021






1 Functional Relationships(s)
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1 Ro 40-7592 (1 and 3 mg/kg, s.c.), a novel COMT inhibitor, 60 min before L-Dopa reinstated both locomotion and rearing during a 2-hr interval after L-Dopa in MPTP mice; control mice were unaffected. Tolcapone catechol-O-methyltransferase Mus musculus