Title : Differential effects of neuroleptic agents on hepatic cytochrome P-450 isozymes in the male rat.

Pub. Date : 1996 Aug 29

PMID : 8781526






2 Functional Relationships(s)
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1 At equipotent doses (with respect to receptor blockade and behavioural tests), the dopamine D2-receptor selective sulpiride and remoxipride gave a conspicuous down-regulation of CYP2C11 and its associated androstenedione 16 alpha-hydroxylation activity as well as of the CYP2C11-specific mRNA. Sulpiride cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 At equipotent doses (with respect to receptor blockade and behavioural tests), the dopamine D2-receptor selective sulpiride and remoxipride gave a conspicuous down-regulation of CYP2C11 and its associated androstenedione 16 alpha-hydroxylation activity as well as of the CYP2C11-specific mRNA. Sulpiride cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus