Title : Role of calcium in stretch-induced release and mRNA synthesis of natriuretic peptides in isolated rat atrium.

Pub. Date : 1996 Oct

PMID : 8781188






2 Functional Relationships(s)
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1 The stretch-induced rise in BNP mRNA was blocked by gadolinium (80 microM), but not by the L-type channel blocker diltiazem (3.0 microM). Gadolinium natriuretic peptide B Rattus norvegicus
2 Gadolinium inhibits the stretch-stimulated rise in BNP mRNA levels in contracting and non-contracting atria, which is similar to its ability to block stretch-activated ir-ANP release, suggesting the involvement of Ca2+-permeable stretch-activated channels. Gadolinium natriuretic peptide B Rattus norvegicus