Title : Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages.

Pub. Date : 1996 Aug 23

PMID : 8780708






1 Functional Relationships(s)
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1 Macrophages pre-treated with acetylsalicylic acid, indomethacin, naproxen or NS-398 and stimulated with LPS showed a marked inhibition on PGE2 production but not on COX-1 or COX-2 mRNA and protein expression. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide mitochondrially encoded cytochrome c oxidase I Homo sapiens