Title : Extracellularly applied ruthenium red and cADP ribose elevate cytosolic Ca2+ in isolated rat osteoclasts.

Pub. Date : 1996 Mar

PMID : 8780250






3 Functional Relationships(s)
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1 The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3",5"-cyclic diphosphate ribose (cADPr). Ruthenium Red ryanodine receptor 2 Rattus norvegicus
2 The objective of the present study was to further characterize this putative RyR by use of the two well-known cell-impermeant RyR modulators, ruthenium red and adenosine 3",5"-cyclic diphosphate ribose (cADPr). Ruthenium Red ryanodine receptor 2 Rattus norvegicus
3 Finally, the cytosolic Ca2+ response to caffeine (5 x 10(-4) M), another RyR modulator, was also strongly attenuated by pretreatment with 5 x 10(-9) M ruthenium red. Ruthenium Red ryanodine receptor 2 Rattus norvegicus