Title : Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

Pub. Date : 1996 Jun

PMID : 8776730






2 Functional Relationships(s)
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1 Overall, these findings provide direct pharmacological evidence that hsp90 function is required to maintain both the hormone-binding activity and stability of the GR protein in intact cells and suggest that hsp90 function may provide a novel target for the modulation of steroid hormone signaling. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens
2 Overall, these findings provide direct pharmacological evidence that hsp90 function is required to maintain both the hormone-binding activity and stability of the GR protein in intact cells and suggest that hsp90 function may provide a novel target for the modulation of steroid hormone signaling. Steroids heat shock protein 90 alpha family class A member 1 Homo sapiens