Title : Nuclear factor kappa B (NF-kappa B), nuclear factor interleukin-6 (NFIL-6 or C/EBP beta) and nuclear factor interleukin-6 beta (NFIL6-beta or C/EBP delta) are not sufficient to activate the endogenous interleukin-6 gene in the human breast carcinoma cell line MCF-7. Comparative analysis with MDA-MB-231 cells, an interleukin-6-expressing human breast carcinoma cell line.

Pub. Date : 1996 Aug 1

PMID : 8774705






3 Functional Relationships(s)
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1 The protein synthesis inhibitor cycloheximide is also a fairly strong inducer of IL-6 in these cells. Cycloheximide interleukin 6 Homo sapiens
2 Finally, when MCF-7 cells were treated with IL-1 beta or TNF-alpha in the presence of cycloheximide, transcription of IL-6 mRNA from the endogenous IL-6 gene was observed. Cycloheximide interleukin 6 Homo sapiens
3 Finally, when MCF-7 cells were treated with IL-1 beta or TNF-alpha in the presence of cycloheximide, transcription of IL-6 mRNA from the endogenous IL-6 gene was observed. Cycloheximide interleukin 6 Homo sapiens