Title : Mechanism of verapamil calcium channel blockade-induced hyperprolactinemia.

Pub. Date : 1996 Jan

PMID : 8772480






3 Functional Relationships(s)
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1 To determine whether the PRL elevation was due to a decrease in hypothalamic generation of DA, we measured the inhibition of PRL by L-dopa before and after inhibition of peripheral decarboxylase activity with carbidopa. Levodopa prolactin Homo sapiens
2 Without verapamil, L-dopa alone and carbidopa-L-dopa caused similar maximum decreases in PRL levels of 83.2 +/- 2.5 and 80.3 +/- 2.0%, respectively. Levodopa prolactin Homo sapiens
3 With verapamil, the PRL maximum decrement with L-dopa was 85.2 +/- 2.7% and with carbidopa-L-dopa was 76.3 +/- 1.9% (P < 0.01). Levodopa prolactin Homo sapiens