Pub. Date : 1996 Sep 13
PMID : 8765467
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we observed an increase in both BAT mass and the expression of UCP mRNA in BAT from obese diabetic mice and their lean littermates following treatment with the thiazolidinedione pioglitazone, a novel insulin-sensitizing agent. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 2 | We found that treatment for 48 hr with pioglitazone caused a 32-fold increase in UCP mRNA, whereas a 7-hr treatment with norepinephrine caused a 24-fold increase in expression. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 3 | Cells treated with pioglitazone for 48 hr, with norepinephrine added during the last 7 hr, demonstrated a 59-fold increase in UCP mRNA. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 4 | However, simultaneous treatment with pioglitazone and repeated treatment norepinephrine for 48 hr yielded a greater than 200-fold increase in UCP mRNA. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 5 | Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 6 | Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 7 | This study shows that pioglitazone exerts a direct effect on BAT cells in vitro by increasing UCP mRNA and protein levels, and that it also synergizes with norepinephrine perhaps by inducing and stabilizing UCP mRNA and/or preventing proteolysis of UCP protein. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 8 | This study shows that pioglitazone exerts a direct effect on BAT cells in vitro by increasing UCP mRNA and protein levels, and that it also synergizes with norepinephrine perhaps by inducing and stabilizing UCP mRNA and/or preventing proteolysis of UCP protein. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |
| 9 | This study shows that pioglitazone exerts a direct effect on BAT cells in vitro by increasing UCP mRNA and protein levels, and that it also synergizes with norepinephrine perhaps by inducing and stabilizing UCP mRNA and/or preventing proteolysis of UCP protein. | Pioglitazone | uncoupling protein 1 (mitochondrial, proton carrier) | Mus musculus |