Title : Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent.

Pub. Date : 1996 Sep 13

PMID : 8765467






4 Functional Relationships(s)
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1 Cells treated with pioglitazone for 48 hr, with norepinephrine added during the last 7 hr, demonstrated a 59-fold increase in UCP mRNA. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 However, simultaneous treatment with pioglitazone and repeated treatment norepinephrine for 48 hr yielded a greater than 200-fold increase in UCP mRNA. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
3 Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
4 Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus