Title : Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors.

Pub. Date : 1996 Aug

PMID : 8764571






3 Functional Relationships(s)
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1 In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs. Nitroprusside heme oxygenase 1 Homo sapiens
2 Sodium nitroprusside increased the levels of heme oxygenase-1 protein but not the levels of heat-shock protein 70 in T98G cells. Nitroprusside heme oxygenase 1 Homo sapiens
3 The increase in content of heme oxygenase-1 mRNA caused by sodium nitro-prusside was completely abolished by the treatment with actinomycin D. Nitroprusside heme oxygenase 1 Homo sapiens