Pub. Date : 1996 Jul
PMID : 8760145
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we tested the hypothesis that ROS are directly involved in the induction of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) and mediate the induction of MnSOD by tumor necrosis factor-alpha (TNF-alpha). | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 2 | In this study, we tested the hypothesis that ROS are directly involved in the induction of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD) and mediate the induction of MnSOD by tumor necrosis factor-alpha (TNF-alpha). | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 3 | Pretreatment of human pulmonary adenocarcinoma cells H441 with the antioxidants N-acetyl-L-cysteine (NAC) and nordihydroguaiaretic acid (NDGA) blocked MnSOD induction by TNF-alpha, implicating ROS as a signaling agent in this pathway. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 4 | Treatment of H441 cells with the exogenous oxidants hydrogen peroxide (H2O2) and diamide increased MnSOD mRNA, supporting the hypothesis that ROS directly affect expression of MnSOD. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 5 | Treatment of H441 cells with the exogenous oxidants hydrogen peroxide (H2O2) and diamide increased MnSOD mRNA, supporting the hypothesis that ROS directly affect expression of MnSOD. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 6 | We conclude that ROS directly alter MnSOD expression and are involved in the induction of MnSOD by TNF-alpha. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 7 | We conclude that ROS directly alter MnSOD expression and are involved in the induction of MnSOD by TNF-alpha. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |