Title : Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells.

Pub. Date : 1996 Jul

PMID : 8760066






1 Functional Relationships(s)
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1 Using IMR fibroblasts, we found that prostaglandin E1 (PGE1) and forskolin, stimulators of cAMP accumulation in young and senescent cells, increased abundance of c-fos and junB mRNA more in young than senescent cells. Colforsin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens