Pub. Date : 1996 Sep
PMID : 8753839
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacologic study of basophil histamine release induced by monocyte chemotactic protein-1 with kinase inhibitors. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | In this study, we examined the effect of a panel of kinase inhibitors on MCP-1-induced histamine release from human basophils to characterize the signaling pathway used by this chemokine. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | Genistein (3 micrograms/ml), an inhibitor of tyrosine kinase, inhibited MCP-1-induced histamine release by 44%. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | It blocked MCP-1-induced histamine release with an IC50 of 3.3 x 10(-8) M indicating a role of PI-3 kinase in this reaction. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |
| 6 | KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. | Histamine | C-C motif chemokine ligand 2 | Homo sapiens |