Pub. Date : 1996 Apr
PMID : 8730126
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We studied the effects of enzyme inhibitors such as bisphosphonates, orthovanadate, calcium, cadmium, and ascorbic acid on PPiase activity of ALP as well as on phosphate ester hydrolysis (Pase) activity and compared these effects to those on CPPD crystal dissolution. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |
| 2 | RESULTS: Bisphosphonates inhibited ALP Pase activity more than ALP PPiase activity at the same concentrations. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |
| 3 | Bisphosphonates at high concentrations inhibited ALP CPPD crystal dissolution. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |
| 4 | The strong inhibitory effects of bisphosphonates on ALP CPPD crystal dissolution compared to those on ALP PPiase activity suggest that bisphosphonates inhibit crystal dissolution by their affinity for the CPPD crystal surface. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |
| 5 | The strong inhibitory effects of bisphosphonates on ALP CPPD crystal dissolution compared to those on ALP PPiase activity suggest that bisphosphonates inhibit crystal dissolution by their affinity for the CPPD crystal surface. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |
| 6 | The strong inhibitory effects of bisphosphonates on ALP CPPD crystal dissolution compared to those on ALP PPiase activity suggest that bisphosphonates inhibit crystal dissolution by their affinity for the CPPD crystal surface. | Diphosphonates | alkaline phosphatase, placental | Homo sapiens |