Pub. Date : 1996 Jul 15
PMID : 8713075
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 2 | The aim of this study was to investigate the effect of the genetic background on the phenobarbital inducibility of cytochrome P-450 2b-9, cytochrome P-450 2b-10 and aldehyde dehydrogenase type 2 mRNAs in mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 3 | In all these mouse strains, phenobarbital induced cytochrome P-450 2b-10 mRNA whereas it could have either a positive or a negative effect on cytochrome P-450 2b-9 expression, depending on the strain and the sex of the mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 4 | Specifically, phenobarbital increased cytochrome P-450 2b-9 expression in C57BL/6J males while it decreased it in DBA/2J mice. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 5 | Genetic analysis revealed that the phenobarbital-inducible phenotype was either a semi-dominant or a recessive trait in F1 animals from a C57BL/6J x DBA/2J cross for the cytochrome P-450 2b-9 and the aldehyde dehydrogenase type 2 genes, respectively. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |