Title : Up-regulation of vascular endothelial growth factor production by iron chelators.

Pub. Date : 1996 Aug 15

PMID : 8706019






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DFO, at concentrations achievable in humans, induced a 3-5-fold increase in VEGF mRNA expression in all cell lines studied. Deferoxamine vascular endothelial growth factor A Homo sapiens
2 The DFO-induced increase in VEGF mRNA expression translated into 6- and 4-fold increases in VEGF protein secretion in conditioned media of retinal pigment epithelial and C6 glioblastoma cells, respectively. Deferoxamine vascular endothelial growth factor A Homo sapiens
3 The DFO-induced increase in VEGF mRNA expression translated into 6- and 4-fold increases in VEGF protein secretion in conditioned media of retinal pigment epithelial and C6 glioblastoma cells, respectively. Deferoxamine vascular endothelial growth factor A Homo sapiens