Title : Calcitonin gene-related peptide (CGRP) in the circular muscle of guinea-pig colon: role as inhibitory transmitter and mechanisms of relaxation.

Pub. Date : 1996 Jan 16

PMID : 8701024






2 Functional Relationships(s)
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Protein Name
Organism
1 CGRP(8-37) (0.3-1.0 microM) produced a partial inhibitory effect (about 50% inhibition) of the relaxant response to capsaicin. Capsaicin calcitonin related polypeptide alpha Homo sapiens
2 Endogenous CGRP mediates part of the relaxant response evoked by stimulation of capsaicin-sensitive primary afferent nerves in the circular muscle of guinea-pig colon, while it is not involved in the apamin and L-NOARG-resistant nonadrenergic noncholinergic (NANC) relaxation produced by electrical field stimulation of intrinsic inhibitory nerves. Capsaicin calcitonin related polypeptide alpha Homo sapiens