Title : Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.

Pub. Date : 1996 Aug 1

PMID : 8698875






2 Functional Relationships(s)
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1 While Th cells from normal subjects (n = 14) and rheumatic disease control patients (n = 9) showed maximal expression of CD40L, after in vitro activation with phorbol myristate acetate (PMA) and ionomycin, at 6 h of culture with diminished levels observed at 24 and 48 h, Th cells from SLE patients (n = 19) maintained high level cell surface expression of CD40L through 24 and 48 h of culture. Tetradecanoylphorbol Acetate CD40 ligand Homo sapiens
2 While Th cells from normal subjects (n = 14) and rheumatic disease control patients (n = 9) showed maximal expression of CD40L, after in vitro activation with phorbol myristate acetate (PMA) and ionomycin, at 6 h of culture with diminished levels observed at 24 and 48 h, Th cells from SLE patients (n = 19) maintained high level cell surface expression of CD40L through 24 and 48 h of culture. Tetradecanoylphorbol Acetate CD40 ligand Homo sapiens