Title : Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro.

Pub. Date : 1996 Mar 15

PMID : 8690897






1 Functional Relationships(s)
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1 We demonstrate here that the beta chemokines, recombinant human macrophage inflammatory protein-1 alpha and -1 beta, RANTES (regulated upon activation, normally T cell expressed and secreted), and macrophage chemotactic peptide-1, are capable of directly costimulating purified human T cell and human T cell clone proliferation and IL-2 production in the presence of anti-CD3 mAb, but not phorbol esters, in vitro. Phorbol Esters interleukin 2 Homo sapiens