Title : Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29.

Pub. Date : 1995 Dec

PMID : 8680718






1 Functional Relationships(s)
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1 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Cycloheximide interleukin 1 alpha Homo sapiens