Title : Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.

Pub. Date : 1996 Jun 4

PMID : 8679526






1 Functional Relationships(s)
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Protein Name
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1 As in the ecDHFR dideazatetrahydrofolate complex, in both the P6(1) and P6(5) structures a water molecule bridges pteridine O4 and Trp-22(N epsilon 1) with ideal geometry for hydrogen bonding, perhaps contributing to the slow release of 5,6,7,8-tetrahydrofolate from the enzyme-product complex. 5,6,7,8-tetrahydrofolic acid dihydrofolate reductase Escherichia coli