Title : Effects of halothane, enflurane and isoflurane on contraction of rat aorta induced by endothelin-1.

Pub. Date : 1995 Dec

PMID : 8672327






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1 Effects of halothane, enflurane and isoflurane on contraction of rat aorta induced by endothelin-1. Enflurane endothelin 1 Rattus norvegicus
2 These studies were performed to see if halothane, enflurane and isoflurane attenuate endothelin-1-evoked contraction and if they interact with endothelium-dependent or -independent vasoactive substances. Enflurane endothelin 1 Rattus norvegicus
3 Isoflurane at 1 and 2 MAC concentration, and enflurane at 2 MAC, induced a rightward shift of the dose-response curve obtained with endothelin-1 in both endothelium denuded and intact rings, associated with a decrease in maximal tension generated in the latter rings. Enflurane endothelin 1 Rattus norvegicus
4 The present study indicates that isoflurane at 1 and 2 MAC, and enflurane at 2 MAC, significantly decreased endothelin-1-induced contraction of isolated rat aorta. Enflurane endothelin 1 Rattus norvegicus