Pub. Date : 1996 Jul
PMID : 8668213
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transactivation by recombinant NFAT1 in Jurkat T cells requires dual stimulation with ionomycin and phorbol 12-myristate 13-acetate; this activity is potentiated by coexpression of constitutively active calcineurin and is inhibited by CsA. | Ionomycin | nuclear factor of activated T cells 2 | Homo sapiens |
| 2 | Immunocytochemical analysis indicates that recombinant NFAT1 localizes in the cytoplasm of transiently transfected T cells and translocates into the nucleus in a CsA-sensitive manner following ionomycin stimulation. | Ionomycin | nuclear factor of activated T cells 2 | Homo sapiens |
| 3 | When expressed in COS cells, however, NFAT1 is capable of transactivation, but it is not regulated correctly: its subcellular localization and transcriptional function are not affected by stimulation of the COS cells with ionomycin and phorbol 12-myristate 13-acetate. | Ionomycin | nuclear factor of activated T cells 2 | Homo sapiens |