Title : The role of a purinergic P2z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate.

Pub. Date : 1996 Apr

PMID : 8666342






2 Functional Relationships(s)
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1 The P2Z-receptor agonist 3"-O-"(4-benzoylbenzoyl)-ATP (BzATP) was twofold more potent than ATP in eliciting cytolysis, which was preceded by a sustained high intracellular Ca2+ concentration; pretreatment with oxidized ATP prevented both the increase in the intracellular Ca2+ concentration and cell death. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate purinergic receptor P2X 7 Rattus norvegicus
2 The P2Z-receptor agonist 3"-O-"(4-benzoylbenzoyl)-ATP (BzATP) was twofold more potent than ATP in eliciting cytolysis, which was preceded by a sustained high intracellular Ca2+ concentration; pretreatment with oxidized ATP prevented both the increase in the intracellular Ca2+ concentration and cell death. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate purinergic receptor P2X 7 Rattus norvegicus