Pub. Date : 1996 Jul 12
PMID : 8663315
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Treatment with wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), or with rapamycin, an inhibitor of the pathway from the insulin receptor to p70/p85 ribosomal S6 protein kinase (p70(s6k)), prevented the induction of HKII mRNA by insulin. | Sirolimus | hexokinase 2 | Homo sapiens |
2 | In addition, rapamycin blocked the insulin-induced expression of an HKII promoter-chloramphenicol acetyltransferase fusion gene transiently transfected into L6 myotubes, whereas PD98059 had no such effect. | Sirolimus | hexokinase 2 | Homo sapiens |