Title : Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin.

Pub. Date : 1996 Jul 12

PMID : 8663315






2 Functional Relationships(s)
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1 Treatment with wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), or with rapamycin, an inhibitor of the pathway from the insulin receptor to p70/p85 ribosomal S6 protein kinase (p70(s6k)), prevented the induction of HKII mRNA by insulin. Sirolimus hexokinase 2 Homo sapiens
2 In addition, rapamycin blocked the insulin-induced expression of an HKII promoter-chloramphenicol acetyltransferase fusion gene transiently transfected into L6 myotubes, whereas PD98059 had no such effect. Sirolimus hexokinase 2 Homo sapiens