Title : De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.

Pub. Date : 1996 May 17

PMID : 8662658






1 Functional Relationships(s)
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Protein Name
Organism
1 Resistance was completely reversed by pretreatment with 25 microM diethylaminobenzaldehyde, a potent ALDH inhibitor. 2-(Diethylamino)benzaldehyde aldehyde dehydrogenase 1 family member A1 Homo sapiens