Pub. Date : 1996 May 17
PMID : 8662657
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HUVEC treated with aspirin lost their capacity to generate PGs but recovery occurred after 3- or 6-h induction of Cox-2 with phorbol ester or IL-1alpha. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Enzyme activity of the newly synthesized Cox-2 in aspirin-treated cells, evaluated after immunoprecipitation, was similar to untreated cells but after 18 h of cell stimulation only 50-60% recovery of Cox-1 was observed. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | However, in acetylsalicylic acid-treated cells, after 6-h stimulation with IL-1alpha, newly synthesized Cox-2 produced less TXB2 than 6-keto-PGF1alpha compared to untreated cells. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |