Pub. Date : 1996 May 24
PMID : 8647872
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice. | Doxorubicin | catalase | Mus musculus |
| 2 | Weak antioxidant capacity, particularly low catalase activity in the heart, may be a factor responsible for the high sensitivity of this organ to doxorubicin-induced oxidative damage. | Doxorubicin | catalase | Mus musculus |
| 3 | As compared to normal controls, transgenic lines expressing catalase activity 60- or 100-fold higher than normal exhibited a significant resistance to doxorubicin-induced cardiac lipid peroxidation, elevation of serum creatine phosphokinase, and functional changes in the isolated atrium. | Doxorubicin | catalase | Mus musculus |
| 4 | The results provide direct evidence for the role of catalase in doxorubicin cardiotoxic responses. | Doxorubicin | catalase | Mus musculus |