Pub. Date : 1996 Mar
PMID : 8643092
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenobarbital induction of hepatic CYP2B1 and CYP2B2: pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 2 | In this regard, we examined the interactions of gender, adult age, and barbiturate dose on the course of phenobarbital induction of hepatic CYP2B1 and CYP2B2. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 3 | We observed that femaleness and youth were associated with the greatest inhibition, so that both the rate and initiation of CYP2B1 and CYP2B2 induction were suppressed most in the young adult (65 days of age) females, followed by the mature adult (150 days of age) females and then by the young adult males, with the mature adult males exhibiting the least suppression of phenobarbital induction. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 4 | The considerably elevated growth hormone pulse amplitudes observed in the young rats of both genders seem to be an additional inhibitory signal antagonizing phenobarbital induction of CYP2B1 and CYP2B2. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 5 | Unlike use of the 10 mg/kg dose, CYP2B1 and CYP2B2 induction by phenobarbital at 1 mg/kg was unaffected by age or gender. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |