Pub. Date : 1996 Feb
PMID : 8636749
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia. | Etoposide | colony stimulating factor 2 | Homo sapiens |
| 2 | We prospectively studied 20 children during initial remission of ALL and 16 children at relapse to assess CSF penetration of etoposide. | Etoposide | colony stimulating factor 2 | Homo sapiens |
| 3 | The CSF etoposide concentration was > or = 10 nmol/L in 20 of 20, five of 10, and two of 11 courses following 300 mg/m2 i.v., 50 mg/m2 orally, and 25 mg/m2 orally, respectively, and was positively related to both the concurrent etoposide plasma concentration (R2 = .64) and to dose (R2 = .73). | Etoposide | colony stimulating factor 2 | Homo sapiens |