Title : Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

Pub. Date : 1996 Feb

PMID : 8632764






1 Functional Relationships(s)
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1 P-glycoprotein and CYP3A4 were constitutively expressed in both LS180/AD50 and LS180/WT cells, and both proteins were up-regulated after treatment with many drugs, including rifampicin, phenobarbital, clotrimazole, reserpine, and isosafrole. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens