Title : Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates.

Pub. Date : 1996 Mar 29

PMID : 8631767






1 Functional Relationships(s)
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1 Studies performed to analyze levels of c-fos mRNA, a gene whose expression is modulated by redox state, demonstrated that only high, apoptotic concentrations of TGF-beta (2.5 ng/ml) produced an increase in the mRNA levels of this gene, the level of induction being similar to that found when cells were incubated in the presence of tert-butyl hydroperoxide. tert-Butylhydroperoxide Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens