Title : Differential expression of urokinase-type plasminogen activator, its receptor, and inhibitors in mouse skin after exposure to a tumor-promoting phorbol ester.

Pub. Date : 1996 Apr

PMID : 8617995






3 Functional Relationships(s)
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1 In the dermis, 5 h after application of phorbol 12-myristate 13-acetate to the skin, uPA mRNA was detected in fibroblast-like cells below and around the skin muscle, and PAI-1 mRNA was detected in stromal cells located above the skin muscle. Tetradecanoylphorbol Acetate serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus
2 After longer exposure to phorbol 12-myristate 13-acetate, the PAI-1 mRNA-expressing stromal cells were located more superficially, apparently moving toward the epidermal layer. Tetradecanoylphorbol Acetate serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus
3 Up to 24 h after the application of phorbol 12-myristate 13-acetate, the intensity of the signal for both uPA and PAI-1 increased, followed by a gradual decrease for up to 7 days. Tetradecanoylphorbol Acetate serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus